Thank you. Very clear and to the point.
There’s one aspect to this that I’m most interested in, and that’s that a molecule can be redesigned with additional pieces stuck on, as in the Chlopyrifos example, or perhaps with a particular group replaced with something functionally identical but structurally different (The pharmaceutical industry is well known for this to keep ahead of expiring patents. IIRC correctly Schering-Plough did just that some years ago with Claritin, to give one example.)
An issue I have with insecticides is more with the industry than with the chemicals: I don’t trust profit-driven entities to be straight with regulators and I’m not entirely comfortable with regulators, for that matter. And I personally am not equipped to understand and intelligently weigh the evidence.
That doesn’t mean that I won’t use “synthetic chemicals”; I will and do. It’s just that I do everything within reason to minimize the need, and then use them judiciously. So It’s very useful to me to have your informed discussion of these things and I value it. Thank you.