If one wanted to be really super careful when pruning out strikes, you could go out and paint Kocide on the spot you want to make the cut the night before then come in the next day and make the cut. Or spray bleach on the cut site right before making the cut.
That should whack back the FB bacteria and hypothetically help to minimize infection at the cut site.
I wonder if there is a correlation between the apple/pear microbiome and incidence of FB outbreaks?... Lots of research coming out now indicates that too much cleanliness and washing in humans (and other mammals) can actually have a negative effect on health and the human skin, and internal gut microbiome. The natural inhibition/outcompetition of FB is probably part of the way that the Bacillus subtilis (Serenade) sprays work.
Makes me wonder if nuking the natural microbiome on apples/pears with copper/streptomycin might set you up for a cycle of needing to spray and increased number of hits from FB. All speculation, of course, but something to think about.