This topic is apparently of high interest to several members here so I’ve created a thread for it.
Are you aware that Persimmon juice is toxic to some species of freshwater fish? Historically, indigenous peoples in the Americas and Asia used the bark to harvest fish from ponds and dammed waterways.
This is getting silly. Bark is not fruit. Pawpaw bark, for example, has way more toxins than fruit.
The plant has good reasons to produce toxins in bark, leaves, shoots, unripe fruit. But it also has good reasons to remove those toxins as fruit ripens, so animals can eat the fruit and distribute the seeds without dying in the process.