Richard,
There are problems with some hybrids as an example not picking up nutrients. Open pollinated corn as an example has very poor yields but picks up 7-9 additional minerals from the soil hybrids cannot. Specifically cobalt is one of the minerals. You might like this article Horses - feeding - horses and ponies on the internet. The minerals are present but the hybrids just can’t pick it up which in cows a lack of cobalt has been associated with brucellosis Cobalt for Soil and Animal Health - The Weston A. Price Foundation. Each situation needs analyzed on a case by case basis and I have no data on tomatoes but this example I gave is a good reason to grow open pollinated corn that yields 80 bushels an acre such as Reid’s yellow dent as opposed to gmo or hybrid corn that yields double or triple the yield of open pollinated if it’s for cows consumption. If the corn is used for making ethanol the gmo is far superior.