Mr. Peterson @RNeal addressed the concerns about his tremors raised by @Schlecht and @Gkight back in 2018 in this thread The dangers of pawpaw consumption. Of course that doesn’t mean they are safe, but that thread contains a good discussion until it heads off in some dogmatic directions. One of the things mentioned in that thread is that KSU is doing some research on which cultivars contain high and low levels of annonacins.
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